Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
نویسندگان
چکیده
منابع مشابه
Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's and type II diabetes (among many others) features a bewildering variety of β-sheet-rich structures in transition from native proteins to ordered oligomers and fibres. The variation in the amino-acid sequences of the β-structures presents a challenge to developing a model system of β-sheets for the study of...
متن کاملAmyloid -sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
The amyloid protein aggregation associated with diseases such as Alzheimer’s, Parkinson’s and type II diabetes (among many others) features a bewildering variety of b-sheet-rich structures in transition from native proteins to ordered oligomers and fibres. The variation in the amino-acid sequences of the b-structures presents a challenge to developing a model system of b-sheets for the study of...
متن کاملMacrocyclic b-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
The amyloid protein aggregation associated with diseases such as Alzheimer’s, Parkinson’s and type II diabetes (among many others) features a bewildering variety of b-sheet-rich structures in transition from native proteins to ordered oligomers and fibres. The variation in the amino-acid sequences of the b-structures presents a challenge to developing a model system of b-sheets for the study of...
متن کاملApple Procyanidins Suppress Amyloid β-Protein Aggregation
Procyanidins (PCs) are major components of the apple polyphenols (APs). We previously reported that treatment with PC extended the mean lifespan of Caenorhabditis elegans (Sunagawa et al., 2011). In order to estimate the neuroprotective effects of PC, we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of Alzheimer's disease...
متن کاملModeling the Aggregation Propensity and Toxicity of Amyloid-β Variants.
Protein aggregation is a hallmark of many neurodegenerative disorders. Alzheimer's disease (AD) is directly linked to deposits of amyloid-β (Aβ) derived from the amyloid-β protein precursor (AβPP), and multiple experimental studies have investigated the aggregation behavior of these amyloids. The present paper reports modeling of the aggregation propensities and cell toxicities of genetic varia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Chemistry
سال: 2012
ISSN: 1755-4330,1755-4349
DOI: 10.1038/nchem.1433